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Updated: Jun 21, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

Pathogenetic and clinical relevance of microRNAs in colorectal cancer

Nicola Valeri1, Carlo M Croce, Muller Fabbri

  • 1Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

Cancer Genomics & Proteomics
|August 7, 2009
PubMed

Insights

Colorectal cancer (CRC) develops through accumulated genetic changes. MicroRNAs (miRNAs) are key players in CRC, offering insights into disease progression and potential treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Colorectal cancer (CRC) is a complex, multistep disease driven by genetic mutations.
  • MicroRNAs (miRNAs), small RNA molecules, are increasingly recognized for their role in cancer development.

Purpose of the Study:

  • This review examines the mechanisms behind miRNA alterations in CRC.
  • It explores the functional impact of these changes on CRC pathogenesis.
  • The review highlights the potential of miRNAs as biomarkers for CRC management.

Main Methods:

  • Literature review of genome-wide profiling studies.
  • Analysis of research on miRNA deregulation in colorectal cancer.
  • Synthesis of findings on miRNA function and clinical utility.

Main Results:

  • Numerous miRNAs are deregulated in CRC, influencing tumorigenesis.
  • Specific miRNA alterations are linked to CRC development and progression.
  • miRNAs show promise as prognostic and predictive markers.

Conclusions:

  • Understanding miRNA alterations is crucial for deciphering CRC pathogenesis.
  • miRNAs represent a significant area for developing novel diagnostic and therapeutic strategies in CRC.
  • Further research into miRNAs could personalize CRC patient management.

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