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PGF isoforms, PLGF-1 and PGF-2, in colorectal cancer and the prognostic significance
Astrid Escudero-Esparza1, Tracey A Martin, Mansel Leigh Davies
1Metastasis & Angiogenesis Research Group, Department of Surgery, Cardiff School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK. escudero-esparzaa@cardiff.ac.uk
Aim:
This study examined the expression of PLGF-1 and PGF-2 in human colorectal cancer and how changes in expression may be linked to prognosis of the disease.
Materials And Methods:
Expression of PLGF transcripts in primary colorectal tumours (n=94) and background tissue (n=80) were analysed by Q-PCR. Immunohistochemistry was carried out on a number of matched background and tumour sections.
Results:
There was a progressive increase in Dukes A to C (430+/-134 versus 674+/-2680) and with TNM 1 to 3 as compared to background tissues (479+/-152 versus 777+/-327 p=0.032). Interestingly, there was an increase in PLGF-1 expression in patients with poor outcome compared with patients remaining disease-free. PGF-2 expression was significantly elevated in tumours compared to normal (4558+/-240 versus 859+/-67.3 p<0.0001). Moreover, expression was increased in patients with poor prognosis compared to those remaining disease free (4585+/-285 versus 3909+/-446).
Conclusion:
There is increased expression of the PLGF isoforms in human colorectal cancer.