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Hypertriglyceridemia: an independent risk factor of chronic kidney disease in Taiwanese adults

Pei-Hsien Lee1, Hung-Yu Chang, Chun-Wu Tung

  • 1Department of Nephrology, Chang Gung Memorial Hospital, Pu-tzu City, Chiayi, Taiwan.

The American Journal of the Medical Sciences
|August 7, 2009
PubMed

Insights

High triglycerides (TGs) are an independent risk factor for chronic kidney disease (CKD) in Taiwanese adults over 40. Early screening for hypertriglyceridemia is crucial for preventing CKD progression.

Area of Science:

  • Nephrology
  • Endocrinology
  • Public Health

Background:

  • Chronic kidney disease (CKD) prevalence is high in Taiwan, especially among older adults.
  • Dyslipidemia is a known CKD progression risk factor, but the role of triglycerides (TGs) is debated.
  • This study investigates hypertriglyceridemia's impact on renal function in Taiwanese adults aged 40+.

Purpose of the Study:

  • To evaluate the association between hypertriglyceridemia and chronic kidney disease (CKD) in Taiwanese adults.
  • To determine if elevated triglyceride levels independently predict CKD risk.
  • To inform public health strategies for CKD prevention in Taiwan.

Main Methods:

  • A community-based medical screening of 18,422 Taiwanese adults (≥40 years) from 2002-2006.
  • CKD defined as estimated glomerular filtration rate <60 mL/min/1.73 m².
  • Multiple logistic regression analysis adjusted for age, BMI, blood pressure, glucose, and cholesterol.

Main Results:

  • CKD prevalence was 24.2% in the study population.
  • Elevated BMI, systolic blood pressure, fasting glucose, and cholesterol were associated with CKD.
  • Hypertriglyceridemia (TG ≥200 mg/dL) showed an adjusted odds ratio of 1.901 for CKD, increasing to 2.205 for TG >500 mg/dL.

Conclusions:

  • Hypertriglyceridemia is an independent risk factor for CKD in Taiwanese adults.
  • Screening for high triglyceride levels is recommended for early CKD detection and prevention.
  • Findings support targeted interventions for dyslipidemia to reduce CKD burden.
Abstract

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