Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

Hypertension IV: Drug Therapy and Lifestyle Modifications

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...

Hypertension and Regulation of Blood Pressure

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Antihypertensive Drugs: Action of Diuretics

Antihypertensive Drugs: Action of Diuretics

Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various tubules...

Alterations in Blood Pressure

Alterations in Blood Pressure

Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Updated assessment of occupational safety and health hazards of climate change.

Journal of occupational and environmental hygiene·2023

Same author

Dysregulation of hepatic metabolism with obesity: factors influencing glucose and lipid metabolism.

The Proceedings of the Nutrition Society·2021

Same author

The role of glucose, insulin and NEFA in regulating tissue triglyceride accumulation: Substrate cooperation in adipose tissue versus substrate competition in skeletal muscle.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2017

Same author

Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study.

European journal of clinical nutrition·2017

Same author

Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study.

European journal of clinical nutrition·2017

Same author

Screening for asymptomatic lymphogranuloma venereum co-infection in men who have sex with men newly diagnosed with HIV, hepatitis C or syphilis.

International journal of STD & AIDS·2015

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Non-invasive Assessment of Microvascular and Endothelial Function

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

Does the DASH diet lower blood pressure by altering peripheral vascular function?

L Hodson¹, K E Harnden, R Roberts

¹Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.

Journal of Human Hypertension

|August 7, 2009

Summary

This summary is machine-generated.

The DASH diet significantly lowered blood pressure (BP) and improved cardiovascular risk factors. However, it did not improve vascular function or adipose tissue blood flow in this study.

More Related Videos

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Related Experiment Videos

Last Updated: Jun 21, 2026

Non-invasive Assessment of Microvascular and Endothelial Function

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Area of Science:

Cardiovascular Health
Nutritional Science
Hypertension Management

Background:

The Dietary Approaches to Stop Hypertension (DASH) diet is known to lower blood pressure.
The mechanisms by which the DASH diet lowers blood pressure, particularly concerning peripheral vascular function, are not fully understood.
Investigating effects on endothelial function, adipose tissue blood flow, and heart rate variability provides insight into DASH diet's impact on cardiovascular health.

Purpose of the Study:

To determine if lowering blood pressure with the DASH diet is associated with changes in peripheral vascular function.
To assess the impact of the DASH diet on endothelial function (flow-mediated vasodilatation - FMD) and subcutaneous adipose tissue blood flow (ATBF).
To evaluate the DASH diet's effects on heart rate variability (HRV) as an indicator of autonomic control.

Main Methods:

A 30-day randomized controlled trial comparing the DASH diet group with a control group, maintaining weight.
Measurements included FMD, ATBF, and HRV, taken under fasting conditions and after glucose ingestion, before and after the intervention.
Biomarkers such as plasma C-reactive protein, LDL-cholesterol, and apolipoprotein B were also assessed.

Main Results:

The DASH diet group showed significant reductions in systolic and diastolic blood pressure (BP).
The DASH diet also led to reductions in plasma C-reactive protein, LDL-cholesterol, and apolipoprotein B.
No significant changes were observed in FMD or ATBF, although heart rate decreased in the DASH-diet group.

Conclusions:

The DASH diet effectively lowers blood pressure and improves key cardiovascular risk markers.
The blood pressure-lowering effects of the DASH diet in this study appear independent of changes in peripheral vascular function.
Further research is needed to fully elucidate the mechanisms behind the DASH diet's cardiovascular benefits.