Related Experiment Video
Updated: Jun 21, 2026
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Carbocyclic 4'-Epiformycin
Jian Zhou1, Minmin Yang, Akin Akdag
1Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849-5312.
Abstract:
Formycin is a naturally occurring biologically responsive C-nucleoside. In pursuing the design and syntheses of novel C-nucleosides, convenient access to carbocyclic C-nucleosides based on the formycin framework was a goal. One such target was carbocyclic 4'-epiformycin (4). This compound is reported via a procedure based on an asymmetric aldol/ring closure methathesis strategy. To provide a preliminary glimpse into the biological characterization of 4 an antiviral assay was conducted. Target 4 was found to be inactive and to lack cytotoxicity to the host cells.
More Related Videos
Related Concept Videos
Structure and Nomenclature of Epoxides
Base-Catalyzed Ring-Opening of Epoxides
Antifungal Agents
Bacterial Phylum Actinobacteria
Acid-Catalyzed Ring-Opening of Epoxides
Production of Antibiotics

