Related Experiment Video
Updated: Jun 21, 2026
10:31
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Profiling proteinuria in children after renal transplantation
Tomás Seeman1, Jiri Dusek, Karel Vondrák
1Department of Pediatrics and Transplantation Center, University Hospital Motol, Charles University Prague, 2nd Faculty of Medicine, V Uvalu 84, 15006 Prague, Czech Republic. tomas.seeman@lfmotol.cuni.cz
Pediatric Nephrology (Berlin, Germany)
|August 7, 2009
Summary
In children after kidney transplantation (RTx), tubular proteinuria is common, affecting 80% of patients and potentially impairing graft function. Glomerular proteinuria is less frequent but linked to chronic allograft nephropathy.
Area of Science:
- Nephrology
- Pediatric Nephrology
- Transplantation Medicine
Background:
- Proteinuria is a frequent complication following renal transplantation (RTx).
- In adult recipients, tubular proteinuria is prevalent and linked to reduced graft survival.
- Limited data exists on proteinuria profiles in pediatric RTx recipients.
Purpose of the Study:
- To investigate and characterize the types of proteinuria in children post-RTx.
- To determine the prevalence of tubular versus glomerular proteinuria in this population.
- To explore associations between proteinuria types and graft function.
Main Methods:
- Cross-sectional study of 53 children (mean age 11.8 years) post-RTx.
- Analysis of morning urine for total protein (PROT), albumin (ALB), and alpha-1-microglobulin (AMG).
- Classification of proteinuria type using the alpha-1-microglobulin/albumin algorithm (AAA).
Main Results:
- 47% of children exhibited pathological total proteinuria.
- Tubular proteinuria was found in 80% of those with pathological proteinuria (20/25).
- Glomerular proteinuria occurred in 20% (5/25), with 3 of 5 cases associated with chronic allograft nephropathy.
- Both AMG and albuminuria showed a negative correlation with estimated glomerular filtration rate (eGFR).
Conclusions:
- Tubular proteinuria is the predominant type in children post-RTx, potentially indicating impaired graft function.
- Glomerular proteinuria, though less common, is significantly associated with chronic allograft nephropathy in pediatric recipients.
- Proteinuria profiling is crucial for assessing graft health in transplanted children.
Related Concept Videos
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...