Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two decades of recipient and donor referrals for heart transplantation to Groote Schuur Hospital, Cape Town, South Africa: A retrospective study.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

Making a difference: 5 years of Cardiac Surgery Intersociety Alliance (CSIA).

Asian cardiovascular & thoracic annals·2024
Same author

Making a Difference: 5 Years of Cardiac Surgery Intersociety Alliance (CSIA).

The Annals of thoracic surgery·2024
Same author

Making a difference: 5 years of Cardiac Surgery Intersociety Alliance (CSIA).

The Journal of thoracic and cardiovascular surgery·2024
Same author

Making a difference: 5 years of Cardiac Surgery Intersociety Alliance (CSIA).

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2024
Same author

In silico Mechanics of Stem Cells Intramyocardially Transplanted with a Biomaterial Injectate for Treatment of Myocardial Infarction.

Cardiovascular engineering and technology·2024
Same journal

Effects of CFR-PEEK plate layup and screw configuration on tibial shaft fracture healing: a simulation study based on a mechanobiological model.

Computer methods in biomechanics and biomedical engineering·2026
Same journal

Metabolic rate-limiting enzyme-associated genes as novel biomarkers for prognosis and treatment response in lung adenocarcinoma.

Computer methods in biomechanics and biomedical engineering·2026
Same journal

An interpretable, clinically-aligned AI paradigm for VTE risk prediction: an approach using LLMs and compound attention.

Computer methods in biomechanics and biomedical engineering·2026
Same journal

Effects of different resistance loads during resisted sprint running on internal stresses of the ankle joint: a finite element analysis.

Computer methods in biomechanics and biomedical engineering·2026
Same journal

Analysis of typical cases of medical infusion pump metering acceptance in nursing scenarios.

Computer methods in biomechanics and biomedical engineering·2026
Same journal

Investigation of biomechanical effect of inverted orthotic insoles on flexible flatfeet.

Computer methods in biomechanics and biomedical engineering·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves
11:00

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Published on: April 9, 2019

Aortic valve leaflet mechanical properties facilitate diastolic valve function.

T M Koch1, B D Reddy, P Zilla

  • 1Department of Mathematics and Applied Mathematics, University of Cape Town, Rondebosch, South Africa.

Computer Methods in Biomechanics and Biomedical Engineering
|August 7, 2009
PubMed
Summary
This summary is machine-generated.

This study numerically simulated aortic valve leaflet mechanics, comparing linear elastic and advanced hyperelastic models. Non-linear, anisotropic models better predicted leaflet behavior, crucial for understanding valve function and scaffold stability.

More Related Videos

Layer Microdissection of Tricuspid Valve Leaflets for Biaxial Mechanical Characterization and Microstructural Quantification
07:34

Layer Microdissection of Tricuspid Valve Leaflets for Biaxial Mechanical Characterization and Microstructural Quantification

Published on: February 10, 2022

Related Experiment Videos

Last Updated: Jun 21, 2026

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves
11:00

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Published on: April 9, 2019

Layer Microdissection of Tricuspid Valve Leaflets for Biaxial Mechanical Characterization and Microstructural Quantification
07:34

Layer Microdissection of Tricuspid Valve Leaflets for Biaxial Mechanical Characterization and Microstructural Quantification

Published on: February 10, 2022

Area of Science:

  • Biomechanics
  • Computational mechanics
  • Materials science

Background:

  • Aortic valve leaflets are complex biological structures.
  • Accurate material modeling is essential for understanding valve mechanics.

Purpose of the Study:

  • To numerically simulate aortic valve leaflet behavior.
  • To compare linear elastic and non-linear hyperelastic anisotropic models.
  • To investigate the impact of material properties on leaflet mechanics.

Main Methods:

  • Numerical simulation of aortic valve leaflet behavior.
  • Comparison of linear elastic and transverse isotropic hyperelastic models.
  • Parameter fitting using uniaxial tensile tests on porcine aortic valve leaflets.

Main Results:

  • Non-linear elastic anisotropic models significantly impacted leaflet mechanics.
  • Increased coaptation and peak stress/strain observed in hyperelastic models.
  • Stress and strain distribution was more even in non-linear elastic leaflets.

Conclusions:

  • Transverse isotropy and hyperelasticity are critical for accurate aortic valve leaflet modeling.
  • Non-linear models provide insights into long-term scaffold stability and mechanotransduction.
  • Findings are relevant for prosthetic valve design and tissue engineering.