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Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses
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[Hypercoagulable workup in ophthalmology. When and what].

F J Muñoz-Negrete1, P Casas-Lleras, M Pérez-López

  • 1Servicio de Oftalmología, Hospital Ramón y Cajal, Madrid, España. franciscojmunoz@telefonica.net

Archivos De La Sociedad Espanola De Oftalmologia
|August 7, 2009
PubMed
Summary
This summary is machine-generated.

Ophthalmologic disorders linked to hypercoagulable states require systematic workup. Identifying congenital and acquired factors like Factor V Leiden and antiphospholipid syndrome is crucial for managing venous and arterial thrombosis.

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Area of Science:

  • Ophthalmology
  • Hematology
  • Genetics

Context:

  • Hypercoagulable states are a significant cause of ophthalmologic disorders.
  • Both congenital and acquired factors contribute to these conditions.
  • A systematic diagnostic approach is essential for accurate diagnosis and management.

Purpose:

  • To outline the diagnostic workup for hypercoagulable states causing ophthalmologic conditions.
  • To differentiate between inherited and acquired causes of thrombosis.
  • To guide the workup based on the type of vascular occlusion (venous vs. arterial).

Summary:

  • Congenital disorders like Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in protein C, S, and antithrombin III commonly cause venous thrombosis.
  • Acquired factors including hyperhomocysteinemia, antiphospholipid syndrome, liver disease, and lifestyle choices contribute to hypercoagulability.
  • Specific workups are recommended for central venous/arterial occlusion and amaurosis fugax, while generally not indicated for non-arteritic ischemic optic neuropathy.

Impact:

  • This systematic approach aids in identifying the underlying causes of vision-threatening thrombotic events.
  • Early detection and management of hypercoagulable states can prevent recurrent ocular vascular occlusions.
  • Tailoring the diagnostic workup based on clinical presentation optimizes patient care and resource utilization.