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Related Experiment Video

Updated: Jun 21, 2026

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
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Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

Development of a quadruple imaging modality by using nanoparticles.

Do Won Hwang1, Hae Young Ko, Suk-Ki Kim

  • 1Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Jongno-gu, Seoul, 110-744, Republic of Korea.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|August 7, 2009
PubMed
Summary
This summary is machine-generated.

This study introduces a novel multimodal nanoparticle imaging system for in vivo applications. This advanced system integrates fluorescence, bioluminescence, and magnetic resonance imaging for versatile diagnostic and therapeutic development.

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Area of Science:

  • Nanotechnology
  • Molecular Imaging
  • Biomedical Engineering

Background:

  • The integration of nanotechnology and molecular imaging offers significant potential for advancing diagnostics and therapeutics.
  • Multimodal imaging systems are crucial for versatile applications, ranging from preclinical cell tracking to clinical diagnostics.

Purpose of the Study:

  • To develop and characterize a multimodal nanoparticle imaging system capable of concurrent fluorescence, bioluminescence, bioluminescence resonance energy transfer (BRET), positron emission tomography (PET), and magnetic resonance (MR) imaging in vivo.
  • To evaluate the system's efficacy in cell tracking and its potential as an imaging tool.

Main Methods:

  • Synthesis of a cobalt-ferrite nanoparticle core encapsulated with rhodamine, conjugated with luciferase and p-SCN-bn-NOTA, and radiolabeled with Gallium-68 (MFBR).
  • Characterization using confocal microscopy to assess transfection efficiency and BRET.
  • In vivo imaging studies in mice using microPET and MR after injecting MFBR-laden cells.

Main Results:

  • The multimodal nanoparticle (MFBR) demonstrated good transfection efficiency in cells and exhibited BRET.
  • A strong correlation was observed between rhodamine, luciferase, and Gallium-68 signals within MFBR.
  • In vivo imaging revealed dose-dependent activity across all modalities and successful tracking of MFBR-laden cells using optical, microPET, and MR imaging.

Conclusions:

  • The developed multimodal nanoparticle imaging system successfully integrates multiple imaging modalities for in vivo applications.
  • This system shows promise as a versatile tool for cell tracking and holds potential for future diagnostic and therapeutic developments.