[Assessement of clinical applicability of acute myocardial infarction markers]

This study was conducted in order to compare sensitivity of AMI markers and to establish the optimal combination of markers of AMI, thus allowing as early application of therapy as possible. In this study we investigated 18 patients (5 women and 13 men) of different ages. There is a difference in early sensitivities ofAMI markers; < or =2 hours after the onset of chest pain myoglobin and troponin T showed greater sensitivity than CK and CKMB. None of the tested markers had the sensitivity greater than 80% before 2-5 hours after the onset of chest pain. The study demonstrated that differences in sensitivities of AMI markers 2-5 hours after the onset of chest pain were slight and are not deemed to be clinically relevant. In the same group relative increase in myoglobin was only transiently higher. High sensitivity of troponin T retained during 10 days also allows the use of this marker in case of late admission of a patient. Therefore, turnaround time and practicality in emergency determination, specificities of these markers, and costs will mainly determine the choice of AMI markers.