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Updated: Jun 21, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Scalarane sesterterpenoids: semisynthesis and biological activity
Haidy N Kamel1, Young B Kim, John M Rimoldi
1Departments of Pharmacognosy and Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Mississippi 38677, USA.
Abstract:
Aiming to improve the potency and selectivity of scalarane sesterterpenoids, a series of natural and semisynthetic analogues, derived from the cytotoxic naturally abundant sesterterpene heteronemin (1), were evaluated for their in vitro antimicrobial and cytotoxic properties. The new sesterterpenes 16-O-methylsesterstatin 4 (6c), 17, 24-dihydroheteronemin (7a), 16, 25-deacetoxy-17, 24-dihydroheteronemin (7b), and 16-deacetoxy-25-methoxy-17, 24-dihydroheteronemin (7c) were structurally defined via physical data analyses. Scalarane sesterterpenes possessing an unsaturated 1,4-dialdehyde moiety showed potent inhibitory activity against methicillin-resistant Staphylococcus aureus at concentrations that are not significantly cytotoxic to mammalian cells. The structural features for the cytotoxicity of scalarane sesterterpenoids are discussed.
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