Sweet syndrome associated with celiac disease

Area of Science:

• Dermatology
• Gastroenterology
• Immunology

Background:

• Neutrophilic dermatoses encompass diverse conditions sharing clinical and histological traits.
• The link between neutrophilic dermatosis and celiac disease remains underexplored in medical literature.

Observation:

• A 43-year-old male patient presented with pruritic, ulcerating pustules on his hands, face, elbows, and neck.
• Clinical and pathological findings were consistent with Sweet syndrome, a neutrophilic dermatosis.

Findings:

• The patient had a history of diverticulitis.
• Successful treatment involved prednisone, dapsone, and a strict gluten-free diet.
• This suggests a potential association between Sweet syndrome and celiac disease.

Implications:

• This case highlights a previously undescribed association between Sweet syndrome and celiac disease.
• A gluten-free diet may be a beneficial therapeutic option for patients with Sweet syndrome and co-existing celiac disease.
• Further research is warranted to elucidate the underlying mechanisms connecting these conditions.