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Updated: Jun 21, 2026
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Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
Published on: May 14, 2014
Role of cooperative binding on noise expression
P S Gutierrez1, D Monteoliva, L Diambra
1Laboratorio de Biología de Sistemas, CREG-UNLP, Av. Calchaqui Km 23.5, CP 1888, Florencio Varela, Argentina.
Summary
Stochastic gene expression fluctuations increase with activator interaction energy, impacting the Hill coefficient and noise levels. This study distinguishes between two cooperative binding mechanisms.
Area of Science:
- Systems Biology
- Biophysics
- Molecular Biology
Background:
- Stochastic fluctuations in gene expression are significant in cellular systems due to small molecule numbers and compartment sizes.
- Understanding these fluctuations is crucial for comprehending gene regulation dynamics.
Purpose of the Study:
- To investigate the role of cooperativity in gene expression's intrinsic fluctuations.
- To propose a stochastic model for gene expression regulation with multiple binding sites.
Main Methods:
- Utilized a stochastic model based on elementary reactions.
- Employed master-equation formalism to analyze intrinsic fluctuations.
- Investigated the impact of interaction energy between activators.
Main Results:
- Found that the Hill coefficient and noise levels increase with elevated interaction energy between activators.
- Demonstrated that increased interaction energy correlates with higher gene expression noise.
- Showcased the model's ability to differentiate between two cooperative binding mechanisms.
Conclusions:
- Cooperativity significantly influences intrinsic fluctuations in gene expression.
- The proposed model provides insights into the relationship between molecular interactions and gene expression noise.
- The study highlights distinct cooperative binding mechanisms affecting gene expression variability.
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