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Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
Published on: January 8, 2013
Bifurcation and chaos in a model of cardiac early afterdepolarizations
Diana X Tran1, Daisuke Sato, Arik Yochelis
1Department of Medicine, Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
Abstract:
Excitable cells can exhibit complex patterns of oscillations, such as spiking and bursting. In cardiac cells, pathological voltage oscillations, called early afterdepolarizations (EADs), have been widely observed under disease conditions, yet their dynamical mechanisms remain unknown. Here, we show that EADs are caused by Hopf and homoclinic bifurcations. During period pacing, chaos always occurs at the transition from no EAD to EADs as the stimulation frequency decreases, providing a distinct explanation for the irregular EAD behavior frequently observed in experiments.
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