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Imipramine and desipramine decrease the GABA-stimulated chloride uptake, and antigabaergic agents enhance their
A Fernández-Teruel1, R M Escorihuela, F Boix
1Department of Pharmacology and Psychiatry, School of Medicine, Autonomous University of Barcelona, Spain.
Abstract:
The present study reports that long-term (18 days) administration of imipramine (IMI, 20 mg/kg) or desipramine (DMI, 15 mg/kg) produced a significant decrease in the GABA-stimulated 36Cl- uptake into membrane vesicles from the cerebral cortex of rats (experiment 1). Experiments 2A, B show that anti-immobility effects of DMI and IMI (subacute treatment) in the forced swimming test are enhanced when a single subconvulsant injection of picrotoxin or pentylenetetrazol is administered to the animals concurrently to the last antidepressant injection. These results are discussed in relation with a current GABAergic hypothesis of depression and antidepressant drug action.