Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Prostanoids in children with joint diseases].

A A Iakovleva, U T Sadykova, Kh M Markov

    Revmatologiia (Moscow, Russia)
    |July 1, 1990
    PubMed
    Summary

    This study found prostaglandins E+A and leukotriene B4 play key roles in childhood arthritis pathogenesis. Measuring these prostanoids in bodily fluids can help assess disease activity and differentiate arthritis types.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Brain blood flow and cerebral insult. Part 2. Cerebral insult pathogenesis and therapy].

    Patologicheskaia fiziologiia i eksperimental'naia terapiia·2013
    Same author

    [Brain blood flow and cerebral insult. Part 2. Regulation of cerebral circulation].

    Patologicheskaia fiziologiia i eksperimental'naia terapiia·2013
    Same author

    [Role of NO/cGMP signaling cascade in the development of opium dependency].

    Eksperimental'naia i klinicheskaia farmakologiia·2013
    Same author

    [Nitrous oxide and atherosclerosis. Pharmacotherapy of atherosclerosis and nitrous oxide].

    Kardiologiia·2011
    Same author

    [Nitrous oxide and atherosclerosis. Pharmacotherapy of atherosclerosis and nitrous oxide].

    Kardiologiia·2011
    Same author

    [Nitrous oxide and atherosclerosis. Nitrous oxide, dysfunction of vascular endothelium, and pathogenesis of atherosclerosis].

    Kardiologiia·2009

    Area of Science:

    • Biochemistry
    • Immunology
    • Pediatrics

    Context:

    • Rheumatoid arthritis and other inflammatory joint diseases affect children.
    • Accurate diagnosis and assessment of disease activity are crucial for effective management.
    • Understanding the role of inflammatory mediators in pediatric arthritis is essential.

    Purpose:

    • To investigate the levels of specific prostanoids, including prostaglandins E+A (PGE+A) and leukotriene B4 (LTB4), in children with inflammatory joint diseases.
    • To establish the role of these prostanoids in the pathogenesis of various forms of arthritis in children.
    • To evaluate the utility of prostanoid determination in biological fluids as a diagnostic and monitoring tool for pediatric arthritis.

    Summary:

    • Radiological methods were employed to measure prostaglandins E+A, F2 alpha (PGF2), and leukotriene B4 (LTB4) in blood plasma and synovial fluid from 138 children.
    • The study identified significant roles for PGE+A and LTB4 in the pathogenesis of arthritis, while PGF2 showed limited involvement.
    • Prostanoid levels in biological fluids emerged as a potential additional laboratory index for assessing overall and local disease activity in pediatric arthritis.

    Impact:

    • Establishes the specific roles of PGE+A and LTB4 in the inflammatory pathways of childhood arthritis.
    • Highlights the potential of prostanoid analysis as a non-invasive biomarker for disease activity and differential diagnosis in pediatric rheumatology.
    • Provides a foundation for future research into targeted therapies modulating these inflammatory mediators in pediatric joint diseases.

    Related Experiment Videos