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Updated: Jun 21, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Ketamine-associated bladder dysfunction.

Tsung-Hsun Tsai¹, Tai-Lung Cha, Chang-Min Lin

¹Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

International Journal of Urology : Official Journal of the Japanese Urological Association

|August 8, 2009

Summary

This summary is machine-generated.

Ketamine abuse can cause severe genitourinary tract dysfunction, including lower urinary tract symptoms and irreversible bladder damage. Early awareness and treatment, such as hyaluronan instillation, may offer symptom relief.

Related Experiment Videos

Last Updated: Jun 21, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Area of Science:

Urology
Toxicology
Pathology

Background:

Ketamine abuse is increasingly recognized for its potential systemic effects.
Genitourinary tract dysfunction is a significant, yet under-reported, complication of ketamine misuse.

Purpose of the Study:

To evaluate the clinical and histological impact of ketamine abuse on the genitourinary system.
To identify key symptoms and pathological changes associated with ketamine-induced bladder dysfunction.

Main Methods:

Study included 11 patients with urinary symptoms and a history of ketamine abuse.
Diagnostic procedures included urinalysis, urine culture, renal function tests, sonography, urodynamic studies, and bladder biopsies.
Histological examination focused on inflammatory cell infiltration.

Main Results:

Common symptoms included dysuria, frequency, urgency, and gross hematuria.
Biopsies revealed granulocyte and mast cell infiltration in bladder tissue, indicating non-specific inflammation.
While standard medications showed limited efficacy, intravesical hyaluronan instillation led to significant symptom improvement.

Conclusions:

Ketamine abuse can lead to severe and potentially irreversible histological changes in the urinary tract.
Clinicians must maintain a high index of suspicion for genitourinary complications in patients with a history of ketamine abuse.
Hyaluronan instillation shows promise for managing ketamine-induced lower urinary tract symptoms.