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Updated: Jun 21, 2026

Computerized Adaptive Testing System of Functional Assessment of Stroke
05:21

Computerized Adaptive Testing System of Functional Assessment of Stroke

Published on: January 7, 2019

Functional outcome measures in contemporary stroke trials.

T J Quinn1, J Dawson, M R Walters

  • 1Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. tjq1t@clinmed.gla.ac.uk

International Journal of Stroke : Official Journal of the International Stroke Society
|August 8, 2009
PubMed
Summary

Stroke clinical trials lack consistent functional outcome assessment methods, leading to varied results. Standardizing assessment tools and methodology is crucial for improving trial quality and data comparability.

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Area of Science:

  • Neurology
  • Clinical Trials
  • Rehabilitation Medicine

Background:

  • Standardized outcome measures are essential for stroke clinical trials.
  • Current functional outcome assessment in stroke trials lacks consensus and consistent best practices.
  • This heterogeneity can impact the quality and comparability of trial data.

Purpose of the Study:

  • To examine the functional assessment methodology used in recent stroke clinical trials.
  • To identify variations in outcome measures and reporting practices.
  • To highlight the need for improved standardization in stroke trial methodology.

Main Methods:

  • A systematic review of interventional stroke trials published between 2001 and 2006 was conducted.
  • Journals included were high-impact publications in stroke, neurology, and internal medicine.

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Last Updated: Jun 21, 2026

Computerized Adaptive Testing System of Functional Assessment of Stroke
05:21

Computerized Adaptive Testing System of Functional Assessment of Stroke

Published on: January 7, 2019

Investigating the Effect of Different Types of Exercise on Upper Limb Functional Recovery in Patients with Right Hemisphere Damage Based on fNIRS
04:43

Investigating the Effect of Different Types of Exercise on Upper Limb Functional Recovery in Patients with Right Hemisphere Damage Based on fNIRS

Published on: February 9, 2024

  • Data on outcome assessment methodology were extracted and analyzed from 126 identified trials.

    • Main Results:

    • 126 stroke trials were reviewed, with functional outcome as the primary endpoint in 100.
    • 47 different outcome measures were used, with the modified Rankin scale (64.3%) and Barthel index (40.5%) being most common.
    • Only 33.3% of trials provided full methodology details, revealing substantial heterogeneity in data collection.

    Conclusions:

    • Significant heterogeneity exists in functional outcome measures and assessment methodology across stroke trials.
    • This variability compromises the ability to compare trial results and conduct meta-analyses.
    • Mandatory explicit description of methodology and increased rigor are necessary to enhance the quality of stroke trial data.