5-Fluorouracil superficial peel for multiple actinic keratoses

Area of Science:

• Dermatology
• Dermatopathology
• Cutaneous oncology

Background:

• Chronically photodamaged skin often exhibits numerous actinic keratoses (AKs).
• Comprehensive treatment of the entire affected skin area is recommended for widespread AKs.

Purpose of the Study:

• To evaluate the efficacy of superficial pulse peeling using a combination of Jessner's solution or glycolic acid with 5-fluorouracil (5-FU) for treating widespread AKs.
• To assess the safety, tolerability, and cost-effectiveness of this therapeutic approach.

Main Methods:

• A combination of Jessner's solution or 70% glycolic acid (GA) with 5% 5-fluorouracil (5-FU) solution was used for superficial pulse peeling.
• Treatments were administered at biweekly intervals to 31 patients with widespread AKs.
• Histopathologic examination of skin biopsies was performed pre- and post-treatment in three patients.

Main Results:

• All patients demonstrated satisfactory outcomes, with complete regression or at least 80% clearance of AK lesions.
• Significant overall improvement in the condition of photodamaged skin was observed.
• The treatment was found to be safe and well-tolerated.

Conclusions:

• Superficial 5-FU pulse peeling is a highly effective, safe, and inexpensive treatment for multiple, diffuse AKs.
• The favorable benefit/cost ratio makes it a valuable option for public health services, particularly in developing countries.