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Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites

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Published on: February 6, 2016

Contact allergy to epoxy (meth)acrylates.

Kristiina Aalto-Korte¹, Soile Jungewelter, Maj-Len Henriks-Eckerman

¹Control of Hypersensitivity Diseases, Finnish Institute of Occupational Health, Helsinki, Finland. kristiina.aalto-korte@ttl.fi

Contact Dermatitis

|August 8, 2009

Summary

Contact allergy to epoxy acrylates like bis-GMA and bis-GA is common, but specific exposure is rarely identified. Cross-reactivity to DGEBA epoxy resin is a likely cause for many reactions.

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Area of Science:

Dermatology
Toxicology
Occupational Health

Background:

Contact allergy to epoxy (meth)acrylates, including bis-GMA, bis-GA, bis-EMA, bis-MA, and GMA, frequently co-occurs with allergy to diglycidyl ether of bisphenol A (DGEBA) epoxy resin.
Understanding these concomitant allergies is crucial for accurate diagnosis and management.

Observation:

A review of patch test data from 1994-2008 at the Finnish Institute of Occupational Health identified 24 patients with allergic reactions to epoxy (meth)acrylates.
Specific exposure was identified in only five patients, linked to dental products (bis-GMA), UV-curable inks (bis-GA), and anaerobic glue (bis-GA).

Findings:

The majority of allergic reactions to bis-GMA, bis-GA, GMA, and bis-EMA were not linked to specific identified exposures.
A significant portion of patients (75%) showed negative reactions to DGEBA epoxy resin, suggesting other allergens may be involved.
Independent reactions to bis-GA were observed, indicating specific sensitization from sources like anaerobic sealants.

Implications:

Cross-reactivity to DGEBA epoxy resin is a probable explanation for many observed allergies to epoxy (meth)acrylates.
Specific sensitization to bis-GA from anaerobic sealants highlights the need to consider these materials in occupational allergy assessments.
Further research is needed to elucidate the complex patterns of sensitization and cross-reactivity within the epoxy (meth)acrylate family.