Related Experiment Video

Updated: Jun 21, 2026

Pediatric Animal Model of Extracorporeal Cardiopulmonary Resuscitation After Prolonged Circulatory Arrest
04:55

Pediatric Animal Model of Extracorporeal Cardiopulmonary Resuscitation After Prolonged Circulatory Arrest

Published on: May 26, 2023

Two-year neurodevelopmental outcomes of infants undergoing neonatal cardiac surgery for interrupted aortic arch: a

Chloe A Joynt1, Charlene M T Robertson, Po-Yin Cheung

  • 1Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

The Journal of Thoracic and Cardiovascular Surgery
|August 8, 2009
PubMed

Insights

Neonatal cardiac surgery for interrupted aortic arch impacts neurodevelopment, with chromosomal abnormalities worsening outcomes. Longer circulatory arrest and low Apgar scores predict lower mental development in unaffected infants.

Area of Science:

  • Pediatric Cardiology
  • Neurodevelopmental Pediatrics
  • Congenital Heart Disease

Background:

  • Interrupted aortic arch is a severe congenital heart defect requiring early surgical intervention.
  • Neonatal cardiac surgery outcomes, particularly neurodevelopmental, require ongoing investigation.
  • Interprovincial collaboration enhances data collection for rare conditions.

Purpose of the Study:

  • To determine neurodevelopmental outcomes in survivors of neonatal interrupted aortic arch repair.
  • To identify predictors of neurodevelopmental outcomes, including preoperative, intraoperative, and postoperative factors.
  • To compare outcomes between infants with and without chromosomal abnormalities.

Main Methods:

  • Multidisciplinary neurodevelopmental assessment at 18-24 months for infants undergoing surgery at <= 6 weeks.
  • Analysis of mental and psychomotor developmental indices.
  • Univariate and multivariate analyses to identify outcome predictors and compare groups.

Main Results:

  • Overall mortality was 3.7% (26 survivors).
  • Mean mental and psychomotor developmental indices were below normative values (75.8 and 72.3, respectively).
  • Children with chromosomal abnormalities had significantly lower scores; these accounted for 29% of variance. In children without chromosomal abnormalities, deep hypothermic circulatory arrest time and 5-minute Apgar score predicted 46% of the variance in mental developmental index.

Conclusions:

  • Neurodevelopmental indices in survivors of neonatal interrupted aortic arch repair are below average.
  • Chromosomal abnormalities are associated with poorer neurodevelopmental outcomes.
  • For infants without chromosomal abnormalities, prolonged deep hypothermic circulatory arrest and low Apgar scores are linked to lower mental development.
Abstract

Related Concept Videos

Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...