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Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

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Related Experiment Video

Updated: Jun 21, 2026

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

Claudication: exercise vs endoluminal revascularization (CLEVER) study update.

Timothy P Murphy1, Alan T Hirsch, Donald E Cutlip

  • 1Rhode Island Hospital Vascular Disease Research Center and Brown Medical School Department of Diagnostic Imaging, Providence, RI 02903, USA. tmurphy@lifespan.org

Journal of Vascular Surgery
|August 8, 2009
PubMed
Summary
This summary is machine-generated.

The CLEVER study compares stenting to exercise for moderate to severe claudication. It evaluates clinical and cost-effectiveness to determine the best treatment for aortoiliac insufficiency.

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Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
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Last Updated: Jun 21, 2026

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
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Published on: April 21, 2023

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
07:48

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia

Published on: June 8, 2019

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Rehabilitation Medicine

Background:

  • Claudication due to aortoiliac insufficiency significantly impacts quality of life.
  • Limited evidence compares invasive revascularization with supervised exercise for this condition.

Purpose of the Study:

  • To compare the clinical and cost-effectiveness of endoluminal revascularization (stenting) versus supervised exercise rehabilitation.
  • To evaluate treatment outcomes in patients with moderate to severe claudication.

Main Methods:

  • Prospective, multicenter randomized clinical trial (CLEVER Study).
  • Enrollment of 217 participants across 28 sites in the US and Canada.
  • Data collection at baseline, 6 months, and 18 months.

Main Results:

  • Primary endpoint: maximum walking duration (MWD) on a graded treadmill test.
  • Secondary endpoints include community walking, cardiovascular disease risk markers, quality of life, and cost-effectiveness.
  • Sixty participants randomized; recruitment projected to end July 2010.

Conclusions:

  • The CLEVER Study will provide crucial data on the comparative effectiveness of two leading treatment modalities for aortoiliac insufficiency.
  • Results will inform clinical decision-making and healthcare policy regarding claudication management.