Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Cyclooxygenase 2 expression in soft tissue leiomyosarcoma.

Megan E Herceg¹, Athanasios C Tsiatis, Jennifer L Halpern

¹Orthopaedics and Rehabilitation Department, Vanderbilt Orthopaedic Institute, 1215 21st Avenue South, Nashville, TN 37232, USA.

Anticancer Research

|August 8, 2009

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tranexamic Acid in Lower Extremity Endoprosthetic Reconstruction for Oncologic Indications: A Retrospective Comparative Study of 617 Patients.

Journal of surgical oncology·2026

Same author

Targeted therapy for DNA damage response and homologous recombination repair defects: The Olaparib Combinations trial.

Cancer·2026

Same author

Multiplex Imaging Mass Cytometry Reveals Prognostic Immunosuppressive Subpopulations and Macrophage-Driven Metastasis in Osteosarcoma.

Cancers·2025

Same author

Should We Stop Assessing Intraoperative Frozen Section Marrow Margins During Ewing Sarcoma Resection?

Clinical orthopaedics and related research·2025

Same author

What Is the Prevalence and Fate of Myxoid Soft-Tissue Tumors With an Indeterminate Diagnosis Prior to Resection?

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews·2025

Same author

Distinguishing benign and malignant myxoid soft tissue tumors: Performance of radiomics vs. radiologists.

PloS one·2025

Cyclooxygenase 2 (COX2) is rarely found in soft tissue leiomyosarcoma and does not impact patient outcomes. This suggests COX2 is not a viable drug target for this cancer.

Area of Science:

Oncology
Molecular Biology
Pathology

Background:

Cyclooxygenase 2 (COX2) is linked to poor prognosis in some cancers.
COX2 expression is variable in leiomyosarcomas but understudied in soft tissue sarcomas.

Purpose of the Study:

To investigate the prevalence and prognostic significance of COX2 in soft tissue leiomyosarcoma.
To determine if COX2 is a potential therapeutic target in this sarcoma subtype.

Main Methods:

Immunohistochemical analysis of COX2 in 33 soft tissue leiomyosarcoma samples.
Correlation of COX2 expression with clinicopathological parameters and patient outcomes.

Main Results:

COX2 staining was observed in only 6 cases, localized to tumor cells near necrosis.

More Related Videos

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

Related Experiment Videos

Last Updated: Jun 21, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

No significant association found between COX2 expression and local recurrence, metastasis, or survival.

Conclusions:

Low frequency and restricted distribution of COX2 in soft tissue leiomyosarcoma.
Absence of prognostic implications suggests COX2 is not a useful therapeutic target for this condition.