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Antiangiogenic properties of viscum album extracts are associated with endothelial cytotoxicity

Sri Ramulu Elluru1, Jean-Paul Duong Van Huyen, Sandrine Delignat

  • 1INSERM UMRS 872, Equipe 16-Immunopathology and Therapeutic Intervention, Centre de Recherche des Cordeliers, 15 Rue de l'Ecole de Médecine, 75006 Paris, France.

Anticancer Research
|August 8, 2009
PubMed
Abstract

Insights

Viscum album (VA) Qu Spez extract significantly inhibited angiogenesis, a key process in tumor growth. Other VA extracts showed no significant effect, suggesting targeted application for cancer therapy.

Area of Science:

  • Oncology
  • Vascular Biology

Background:

  • Viscum album (VA) extracts are utilized in cancer therapy, exhibiting cytotoxicity to tumor and endothelial cells.
  • Tumor growth, sustenance, and metastasis are critically dependent on angiogenesis.
  • Inhibiting angiogenesis presents a promising therapeutic strategy for cancer treatment.

Purpose of the Study:

  • To investigate the antiangiogenic effects of different Viscum album (VA) extracts.
  • To evaluate the potential of VA extracts as inhibitors of tumor angiogenesis.

Main Methods:

  • Cytotoxicity assessed via Annexin V/propidium iodide staining in endothelial cells.
  • In vitro antiangiogenic activity evaluated by vascular formation in matrigel assays.
  • In vivo efficacy tested using matrigel plugs and systemic treatment in mice.

Main Results:

  • Combined systemic and intra-matrigel administration of VA Qu Spez extract significantly inhibited angiogenesis.
  • VA P extract demonstrated no significant impact on vessel formation.

Conclusions:

  • The findings suggest that specific Viscum album (VA) extracts, particularly VA Qu Spez, can inhibit angiogenesis.
  • These results may inform improved therapeutic strategies for cancer utilizing VA extracts targeting angiogenesis.

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