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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Drug Administration and Therapy Phases: Overview01:26

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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
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Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
Production of Pharmaceuticals01:30

Production of Pharmaceuticals

Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...
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Updated: Jun 21, 2026

Discovery and Synthesis Optimization of Isoreticular Al(III) Phosphonate-Based Metal-Organic Framework Compounds Using High-Throughput Methods
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Looking forward in pharmaceutical process chemistry.

Ian W Davies1, Christopher J Welch

  • 1Merck, 126 East Lincoln Avenue, Rahway, NJ 07065-0900, USA.

Science (New York, N.Y.)
|August 8, 2009
PubMed
Summary
This summary is machine-generated.

Process chemistry synthesizes drug candidates and creates efficient manufacturing processes. Innovation, platform technologies, and academic collaboration are key for future drug discovery advancements.

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Area of Science:

  • Pharmaceutical Sciences
  • Chemical Engineering
  • Drug Development

Background:

  • Process chemistry is crucial for scaling drug candidate synthesis for clinical trials.
  • Developing safe, robust, and cost-effective manufacturing processes is a primary goal.
  • Innovative problem-solving is essential for addressing evolving scientific and market challenges.

Purpose of the Study:

  • To highlight the evolving role of process chemistry in drug discovery and development.
  • To emphasize the importance of technological innovation and collaboration.
  • To outline future directions for enhancing efficiency and success rates.

Main Methods:

  • Focus on synthesis of drug candidates at scale.
  • Development of safe, robust, and cost-effective manufacturing processes.
  • Leveraging platform chemical technologies and high-throughput experimentation.

Main Results:

  • Platform technologies enable rapid problem-solving and accelerate drug discovery.
  • Integrating platforms across the discovery-development continuum streamlines processes.
  • Enhanced collaboration with academia provides access to novel solutions.

Conclusions:

  • Process chemistry innovation is vital for overcoming future challenges.
  • Platform technologies and high-throughput experimentation are key enablers.
  • Academic-industry partnerships are essential for training future scientists and driving innovation.