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Updated: Jun 21, 2026
09:33
Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
Published on: August 25, 2023
Candidate genes associated with malignant pheochromocytomas by genome-wide expression profiling
Insoo Suh1, Daniel Shibru, Graeme Eisenhofer
1Department of Surgery, University of California, San Francisco, CA 94143-1674, USA.
Annals of Surgery
|August 8, 2009
Summary
Gene expression profiling accurately distinguishes benign from malignant pheochromocytomas. This study identifies key molecular pathways and genes, offering new insights into malignant tumor development.
Area of Science:
- Endocrinology
- Oncology
- Genomics
Background:
- Malignant pheochromocytoma transformation mechanisms are unclear.
- Histopathological criteria for distinguishing benign from malignant tumors are lacking.
Purpose of the Study:
- To elucidate molecular mechanisms of malignant pheochromocytoma.
- To identify gene expression differences between benign and malignant tumors.
Main Methods:
- Genome-wide expression profiling of 58 pheochromocytomas (29 benign sporadic, 16 benign hereditary, 13 malignant).
- Utilized technical and biological replication for robust analysis.
Main Results:
- Supervised analysis clearly separated benign and malignant tumors.
- Differentially expressed genes involved in signal transduction, transcription, and carcinogenesis pathways.
- A combination of 5 genes achieved 0.96 area under the ROC curve for diagnosis.
Conclusions:
- Differentially expressed genes accurately distinguish benign from malignant pheochromocytomas.
- Identified novel genes and molecular pathways implicated in malignant transformation.
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