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MICB0106 gene polymorphism is associated with ulcerative colitis in central China
1Department of Gastroenterology and Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan, People's Republic of China.
International Journal of Colorectal Disease
|August 8, 2009
Summary
The MICB0106 allele is linked to ulcerative colitis (UC) in central China. While soluble MICA (sMICA) is elevated in UC patients, it does not correlate with the MICB0106 genotype.
Area of Science:
- Immunogenetics
- Gastroenterology
- Autoimmune Diseases
Background:
- Nonclassical MHC class I chain-related genes A and B (MICA and MICB) are polymorphic and expressed on epithelial cells.
- MICA and MICB gene variations are implicated in autoimmune diseases, but their role in ulcerative colitis (UC) is unestablished.
Purpose of the Study:
- To determine the association between MICB exon 2-4 polymorphisms and soluble MICA (sMICA) levels with UC susceptibility in central China.
Main Methods:
- Genotyping of MICB exon 2-4 polymorphisms in 105 UC patients and 213 healthy controls using PCR-SSCP.
- Quantification of serum sMICA levels in a subset of patients and controls via ELISA.
Main Results:
- The MICB0106 allele frequency was significantly higher in UC patients (19.0%) compared to controls (8.9%), particularly in extensive colitis, severe disease, and male patients.
- Serum sMICA levels were markedly elevated in UC patients (604.41 pg/ml) versus controls (175.37 pg/ml).
- No association was found between MICB0106 genotype and sMICA levels.
Conclusions:
- The MICB0106 allele is a risk factor for UC in the Han Chinese population of central China.
- Elevated sMICA expression is characteristic of UC but independent of MICB0106 genotype.
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