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Updated: Jun 21, 2026
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A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors
Published on: April 29, 2022
PPEF/PP7 protein Ser/Thr phosphatases
Alexandra V Andreeva1, Mikhail A Kutuzov
1Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA. aandreev@uic.edu
Cellular and Molecular Life Sciences : CMLS
|August 8, 2009
Summary
Plant PP7 phosphatases are involved in light and stress signaling pathways. While structurally similar to animal PPEFs involved in vision, they are not direct orthologs and have distinct roles.
Area of Science:
- Biochemistry
- Molecular Biology
- Plant Science
Background:
- Protein Ser/Thr phosphatases are crucial enzymes in cellular signaling.
- The PPEF/PP7 subfamily is one of five PPP phosphatase groups.
- Plant PP7 phosphatases are implicated in light and stress response pathways.
Purpose of the Study:
- To investigate the evolutionary and functional relationship between plant PP7 and animal PPEF phosphatases.
- To clarify the distinct roles of plant and non-plant PPEF/PP7 family members.
Main Methods:
- Comparative analysis of protein domain architecture.
- Review of existing literature on PPEF/PP7 function in plants and animals.
Main Results:
- Plant PP7 and animal PPEF phosphatases share structural similarities in catalytic domains.
- Expression profiling suggests mammalian PPEF involvement in stress response, cell survival, growth, proliferation, and oncogenesis.
- Despite functional links in light perception, plant and animal PPEF/PP7 representatives exhibit distinct domain structures and are not orthologs.
Conclusions:
- Plant PP7 and animal PPEF phosphatases represent divergent evolutionary paths.
- Distinct domain architectures suggest specialized functions in their respective organisms.
- Further research is needed to fully elucidate the specific roles of plant PP7 in signaling pathways.
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