Related Experiment Videos
[Immunologic characterization of alpha-bungarotoxin binding proteins in human microcellular lung carcinoma]
1Klinika za nespecificna plućna oboljenja, Podhrastovi, Sarajevo.
Plucne Bolesti : Casopis Udruzenja Pneumoftiziologa Jugoslavije = the Journal of Yugoslav Association of Phthisiology and Pneumology
|July 1, 1990
Abstract:
Alpha Bungarotoxin, neurotoxin of long chain, is used very often as a tool for studying of muscular nicotinic acetylcholine receptors. It was found out that six human small-cell carcinoma cell lines tested had alpha Bungarotoxin binding sites. Using monoclonal and polyclonal antibodies alpha Bungarotoxin binding sites were found more similar to neuronal nicotinic receptors than to muscular nicotinic receptors. Hyperpolarization effect of alpha Bungarotoxin on small cell lung cancer cells could not be explained by the presence of ionic channels.