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Updated: Jun 21, 2026

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits
Published on: July 21, 2023
[Advances of nucleus pulposus cells for treating intervertebral disc degeneration]
Feng Wang1, Yuntao Wang, Xiaotao Wu
1Department of Orthopaedics, Affiliated Zhongda Hospital of Southeast University, Nanjing Jiangsu, 210009, P.R. China.
Objective:
To introduce the research of nucleus pulposus cells for treating intervertebral disc degeneration.
Methods:
The original articles in recent years about nucleus pulposus cells for treating intervertebral disc degeneration were extensively reviewed, and retrospective and comprehensive analysis was performed.
Results:
Nucleus pulposus cells are not only simply a remnant of embryonic notochordal cells, but have also an important influence on the well-being of the whole disc. The biological treatment strategies aim to regenerate the disc by either trying to improve the micro-environment within the disc or to increase the population of the nucleus pulposus, which includes transplanting mesenchymal stem cells to differentiate into nucleus-like cells in the degenerated intervertebral disc.
Conclusion:
Nucleus pulposus cells or nucleus pulposus like cells based cell transplantation methods prove to be a promising and realistic approach for the intervertebral disc regeneration.
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