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Updated: Jun 21, 2026

A Modified Inflammatory Pain Model to Study the Analgesic Effect in Mice
Published on: November 15, 2024
Study of analgesic and anti-inflammatory effects of lappaconitine gelata
Ying-zi Wang1, Yong-qing Xiao, Chao Zhang
1College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
Objective:
To explore the analgesic and anti-inflammatory effects of lappaconitine gelata (LA).
Methods:
The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate method in the mouse, and the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were used for investigation on the analgesic and anti-inflammatory effects of LA.
Results:
The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate methods was significantly inhibited by LA. In addition, the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were all significantly suppressed by LA.
Conclusion:
LA has the analgesic and anti-inflammatory effects.