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Updated: Jun 21, 2026
Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells
Published on: October 22, 2012
T-cell epitope mapping
1Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53201-2178, USA. laurent.malherbe@bcw.edu
Objective:
To provide a general overview of T-cell epitope mapping and its relevance to physicians practicing allergy/ immunology.
Data Sources:
The PubMed database was searched for articles published from January 1, 1990, through December 31, 2008, for primary and review articles on T-cell epitope mapping. The keywords searched were CD4 T cell, major histocompatibility complex class II, epitope mapping, methods, and allergen.
Study Selection:
Specific articles on commonly used mapping techniques were retrieved, along with articles on the use of epitope mapping in models of allergy.
Results:
A synopsis of T-cell epitope mapping, with emphasis on the relevance to allergy is presented.
Conclusions:
T-cell epitope mapping studies have already allowed the identification of several major T-cell allergens. Improvement in T-cell epitope mapping techniques and in computer algorithms capable of predicting peptides recognized by CD4 T cells will help refine our understanding of the immune responses to allergens and may also offer the possibility of peptide therapy in the future.
