Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ucenprubart is an agonistic antibody to CD200R with the potential to treat inflammatory skin disease: preclinical development and a phase 1 clinical study.

Nature communications·2025
Same author

A Phase-Appropriate Risk Assessment Strategy in Support of the Safety of Peptide and Oligonucleotide-Related Impurities.

The AAPS journal·2025
Same author

Preclinical immunogenicity risk assessment of biotherapeutics using CD4 T cell assays.

Frontiers in immunology·2024
Same author

Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey.

Regulatory toxicology and pharmacology : RTP·2024
Same author

Proceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals.

mAbs·2024
Same author

Survey Outcome on Immunogenicity Risk Assessment Tools for Biotherapeutics: an Insight into Consensus on Methods, Application, and Utility in Drug Development.

The AAPS journal·2023

Related Experiment Video

Updated: Jun 21, 2026

Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells
13:58

Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells

Published on: October 22, 2012

T-cell epitope mapping.

Laurent Malherbe1

  • 1Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53201-2178, USA. laurent.malherbe@bcw.edu

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|August 12, 2009
PubMed
Summary

T-cell epitope mapping identifies major allergens and advances understanding of immune responses. Improved techniques and algorithms may enable future peptide therapies for allergies.

Area of Science:

  • Immunology
  • Allergy Research

Background:

  • T-cell epitope mapping is crucial for understanding allergic immune responses.
  • Identifying specific T-cell epitopes on allergens is key to developing targeted therapies.

Purpose of the Study:

  • To offer a comprehensive overview of T-cell epitope mapping.
  • To highlight the significance of T-cell epitope mapping for allergy and immunology practitioners.

Main Methods:

  • A systematic literature search of the PubMed database was conducted for articles published between 1990 and 2008.
  • Keywords included "CD4 T cell," "major histocompatibility complex class II," "epitope mapping," "methods," and "allergen."
  • Articles focusing on common mapping techniques and their application in allergy models were selected.

More Related Videos

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
08:09

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

Published on: March 24, 2017

Related Experiment Videos

Last Updated: Jun 21, 2026

Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells
13:58

Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells

Published on: October 22, 2012

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
08:09

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

Published on: March 24, 2017

Main Results:

  • The review synthesizes current knowledge on T-cell epitope mapping.
  • Emphasis is placed on the application and relevance of these techniques within the field of allergy.

Conclusions:

  • T-cell epitope mapping has successfully identified several key allergens.
  • Advancements in mapping techniques and predictive algorithms will enhance the understanding of allergen-specific immune responses.
  • Future developments may lead to novel peptide-based therapies for allergic diseases.