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[Affection of target organs in hypertensive patients with and without metabolic syndrome]

G Kh Sharipova, M A Saidova, T V Balakhonova

    Terapevticheskii Arkhiv
    |August 12, 2009
    PubMed

    Insights

    Metabolic syndrome accelerates target organ damage in patients with arterial hypertension (AH). This study found that metabolic syndrome leads to earlier and more severe heart, kidney, and vessel damage in AH patients.

    Area of Science:

    • Cardiology
    • Nephrology
    • Vascular Medicine

    Background:

    • Arterial hypertension (AH) is a significant risk factor for cardiovascular and renal diseases.
    • Metabolic syndrome (MS) is increasingly recognized as a contributor to cardiovascular complications.
    • Understanding the interplay between AH, MS, and target organ damage is crucial for effective management.

    Purpose of the Study:

    • To investigate the impact of metabolic syndrome (MS) on target organ damage in patients with arterial hypertension (AH).
    • To compare the severity of cardiac, renal, and vascular damage in hypertensive patients with and without MS.
    • To assess the correlation between metabolic abnormalities and specific markers of organ damage.

    Main Methods:

    • Enrolled 303 patients with AH (grades 1-3), divided into groups with and without MS.
    • Assessed lipid profile, blood glucose, glomerular filtration rate, and microalbuminuria (MAU).
    • Utilized 24-hour blood pressure monitoring, echocardiography, and carotid artery Doppler ultrasonography.

    Main Results:

    • Early AH showed diastolic left ventricular (LV) dysfunction, reduced glomerular filtration rate, and MAU.
    • AH grade 2 was associated with LV remodeling; grade 3 showed increased LV myocardial mass (LVMM) and intima-media thickness (TIM).
    • Strong correlations were observed between diastolic dysfunction, MAU, LVMM, and TIM.

    Conclusions:

    • Metabolic syndrome exacerbates target organ damage in arterial hypertension.
    • Hypertensive patients with MS experience earlier and more severe cardiac, renal, and vascular alterations.
    • Early detection and management of MS are vital in AH patients to prevent progressive organ damage.
    Abstract

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