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Related Experiment Video

Updated: Jun 21, 2026

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
05:45

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Published on: April 26, 2019

[Hirschsprung's disease].

Tomoaki Taguchi1, Satoshi Ieiri

  • 1Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Nihon Geka Gakkai Zasshi
|August 12, 2009
PubMed
Summary
This summary is machine-generated.

While surgery often cures Hirschsprung's disease, long-term bowel function can be suboptimal. Many adults experience incontinence or soiling, impacting quality of life despite satisfactory outcomes for most.

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Immunostaining to Visualize Murine Enteric Nervous System Development
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Immunostaining to Visualize Murine Enteric Nervous System Development

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Last Updated: Jun 21, 2026

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
05:45

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Published on: April 26, 2019

Immunostaining to Visualize Murine Enteric Nervous System Development
07:54

Immunostaining to Visualize Murine Enteric Nervous System Development

Published on: April 29, 2015

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Quality of Life Studies

Context:

  • Hirschsprung's disease is a congenital condition often treated surgically.
  • While definitive surgery aims for a cure, long-term functional outcomes require evaluation.
  • Adult patients' perspectives on postoperative bowel and social function are crucial.

Purpose:

  • To assess the long-term general condition, bowel function, and social performance in adults treated for Hirschsprung's disease in childhood.
  • To identify the prevalence of satisfactory vs. perfect bowel function post-surgery.
  • To understand the impact of residual bowel dysfunction on quality of life.

Summary:

  • A questionnaire survey of adults with a history of Hirschsprung's disease revealed that 87.5% reported satisfactory bowel function.
  • However, only 25% achieved a perfect evacuation score, with 17.5% experiencing incontinence and 17.5% reporting soiling.
  • Genitourinary function was generally normal, and social outcomes including marriage and parenthood were reasonable.

Impact:

  • Despite generally satisfactory outcomes, the persistence of incontinence and soiling highlights a need for improved surgical techniques.
  • Pediatric surgeons must strive for complete bowel function restoration to enhance long-term quality of life for Hirschsprung's disease patients.
  • This study underscores the importance of long-term follow-up and patient-reported outcomes in evaluating surgical success for Hirschsprung's disease.