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Updated: Jun 21, 2026

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
Published on: February 9, 2016
The absorption characteristics of bifendate solid dispersion in rat intestinal tissue
Juan Cheng1, Zheng Hong Wu, Qineng Neng Ping
1Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, PR China.
Aim:
Research on bifendate intestinal absorption.
Method:
The single passed intestinal backflow method was used. Bifendate with different concentrations, bifendate with and without 2,4-dinitrophenol, verapamil, and probenecid, and solid state of bifendate in different systems were studied.
Result:
Change of concentration and the presence of energy inhibitor, P-glycoprotein inhibitor and multidrug-resistant protein inhibitor did not affect the K(a) of bifendate intestinal absorption; there were obvious differences among intestinal absorption of native drug, solid dispersion, and physical mixtures.
Conclusion:
The result indicated that the intestinal absorption mechanism of bifendate is passive transport. Solid state of bifendate in different systems could affect the intestinal absorption.
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