Related Experiment Video

Updated: Jun 21, 2026

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
08:00

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

Changing the clinical picture of challenging tumors: tales becoming reality?

Camilo Moulin1, Otto Metzger-Filho, Ahmad Awada

  • 1Jules Bordet Institute, 121 Bd. de Waterloo, 1000 Brussels, Belgium. camilo.moulin@bordet.be

Future Oncology (London, England)
|August 12, 2009
PubMed

Insights

Targeted cancer therapies show promise, but benefits vary by tumor type. This study examines novel treatments for rare, challenging neoplasms often overlooked in clinical research.

Area of Science:

  • Oncology
  • Molecular Biology
  • Translational Medicine

Background:

  • Cancer treatment increasingly relies on tumor biology and targeted therapies.
  • Intracellular signaling pathway understanding fuels advancements in cancer treatment.
  • Uneven distribution of therapeutic benefits across cancer types necessitates further research.

Purpose of the Study:

  • To evaluate new insights and potential gains from novel therapies.
  • To focus on rare and challenging neoplasms often neglected in clinical practice.
  • To address the considerable challenges posed by these tumors to clinical oncology.

Main Methods:

  • Review of current literature on targeted therapies for neoplastic diseases.
  • Analysis of intracellular signaling pathways relevant to cancer progression.
  • Evaluation of clinical data and research trends for rare tumor types.

Main Results:

  • Identification of emerging therapeutic strategies for specific cancer subtypes.
  • Assessment of the potential impact of these strategies on treatment outcomes.
  • Highlighting the need for increased research focus on underrepresented neoplasms.

Conclusions:

  • Novel therapeutic approaches offer potential for challenging, rare cancers.
  • Further investigation is crucial to improve treatment for these neoplasms.
  • Personalized medicine based on tumor biology is key to advancing oncology.

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...