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Updated: Jun 21, 2026
Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics
Published on: November 30, 2012
Recent advances in targeted anti-vasculature therapy: the neuroblastoma model
F Pastorino1, D Di Paolo, M Loi
1Experimental Therapy Unit, Laboratory of Oncology, G. Gaslini Children's Hospital, Largo G. Gaslini 5, 16148 Genoa, Italy. fabiopastorino@ospedale-gaslini.ge.it
Abstract:
Novel anti-vasculature strategies that are emerging for the treatment of cancer and for the inhibition of angiogenesis may be a promising new tool for the adjuvant therapy of malignant tumours. Over the last fifteen years, several reports have been published concerning the relationship between tumour progression and angiogenesis in experimental models of neuroblastoma in vitro and in vivo. Moreover, a high vascular index in neuroblastoma correlates with poor prognosis, suggesting dependence of aggressive tumour growth on active angiogenesis. Here, we present an overview of the most recent advances in anti-vasculature therapy of neuroblastoma, and describe some preclinical results as well as future perspectives.
Insights
Novel anti-vasculature therapies show promise for treating neuroblastoma by inhibiting tumor angiogenesis. Targeting tumor vasculature may improve outcomes for malignant tumors, offering new adjuvant treatment options.
Area of Science:
- Oncology
- Vascular Biology
- Cancer Therapeutics
Background:
- Neuroblastoma tumor progression is linked to angiogenesis.
- A high vascular index in neuroblastoma correlates with poor prognosis.
- Active angiogenesis supports aggressive tumor growth.
Purpose of the Study:
- To review recent advances in anti-vasculature therapy for neuroblastoma.
- To discuss preclinical results and future directions in this field.
Main Methods:
- Literature review of studies on neuroblastoma and angiogenesis.
- Analysis of experimental models (in vitro and in vivo).
Main Results:
- Anti-vasculature strategies are emerging as potential adjuvant therapies.
- Inhibition of angiogenesis is a key target for neuroblastoma treatment.
Conclusions:
- Anti-vasculature therapy represents a promising approach for neuroblastoma.
- Further research into preclinical results and future perspectives is warranted.
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