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Published on: December 19, 2019
Multiple intravascular papillary endothelial hyperplasia affecting skin and bone.
Y Higashi1, Y Uchida, N Yoshii
1Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. higashiy@m.kufm.kagoshima-u.ac.jp
Clinical and Experimental Dermatology
|August 12, 2009
Summary
This case study details a rare instance of multiple intravascular papillary endothelial hyperplasia (IPEH) lesions on the skin and bone of a 75-year-old man. Liver dysfunction may have induced these vascular growths through microthrombus formation.
Area of Science:
- Vascular pathology
- Dermatopathology
- Oncology
Background:
- Intravascular papillary endothelial hyperplasia (IPEH) is a rare benign vascular proliferation.
- Multiple IPEH lesions are exceptionally uncommon, particularly when affecting both skin and bone.
Observation:
- A 75-year-old male presented with numerous recurrent black papules across his body.
- Over three years, 20 skin lesions were surgically removed and diagnosed as IPEH.
- A similar vascular lesion was identified on the patient's tibia.
Findings:
- Histological confirmation of intravascular papillary endothelial hyperplasia (IPEH) in multiple cutaneous lesions.
- Identification of a concurrent IPEH lesion in the bone (tibia).
- The patient had a history of hepatitis C, hepatoma, and coagulopathy.
Implications:
- This case highlights the extreme rarity of disseminated IPEH involving both skin and bone.
- The findings suggest a potential link between liver dysfunction, coagulopathy, and the development of multiple IPEH lesions.
- Microthrombus formation secondary to hepatic dysfunction is proposed as the underlying mechanism.
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