Related Experiment Video
Updated: Jun 21, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Erysipeloid: a review
S Veraldi1, V Girgenti, F Dassoni
1Institute of Dermatological Sciences, University of Milan, IRCCS Foundation, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy. stefano.veraldi@unimi.it
Erysipeloid is a skin infection from Erysipelothrix rhusiopathiae, often affecting hands. While typically mild, it can rarely cause serious endocarditis, particularly in males with pre-existing heart valve damage.
Area of Science:
- Dermatology
- Infectious Diseases
- Microbiology
Background:
- Erysipeloid is an occupational skin infection caused by Erysipelothrix rhusiopathiae.
- It typically presents as localized, erythematous edema on the hands, sometimes with vesicles or bullae.
- Erysipelothrix rhusiopathiae can also cause rare but severe endocarditis.
Purpose of the Study:
- To describe the clinical characteristics of erysipeloid infections.
- To outline the diagnostic criteria for erysipeloid.
- To discuss the potential for Erysipelothrix rhusiopathiae to cause systemic infection, specifically endocarditis.
Main Methods:
- Clinical case review and analysis of patient history, focusing on occupational exposure.
- Physical examination of skin lesions.
- Review of diagnostic criteria and treatment outcomes.
Main Results:
- Erysipeloid lesions are characterized by well-defined, raised erythematous borders, often on the hands.
- Symptoms can range from asymptomatic to mild pruritus, pain, and fever.
- Erysipelothrix rhusiopathiae endocarditis is rare, affects males predominantly, and typically involves pre-existing damaged valves (aortic valve).
Conclusions:
- Diagnosis of localized erysipeloid relies on occupational history, characteristic skin lesions, and response to antibiotics.
- While cutaneous erysipeloid usually resolves quickly with penicillin or cephalosporin, the potential for endocarditis necessitates awareness, especially in at-risk populations.
- Endocarditis due to Erysipelothrix rhusiopathiae is not associated with prosthetic valves or intravenous drug use.
Related Concept Videos
Clinical Applications of Epidermal Stem Cells
EPS and iPS Cells in Disease Research
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Plague
