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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

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Objective assessments of allergic and nonallergic rhinitis in young children

B L K Chawes1, E Kreiner-Møller1, H Bisgaard1

  • 1Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte Copenhagen, Denmark.

Allergy
|August 12, 2009
PubMed

Insights

Allergic rhinitis in children is linked to irreversible nasal obstruction and eosinophilia, indicating different pathologies than nonallergic rhinitis. This study highlights distinct nasal inflammation and airway changes in childhood rhinitis.

Area of Science:

  • Pediatric Allergy and Immunology
  • Otorhinolaryngology
  • Respiratory Medicine

Background:

  • Allergic and nonallergic rhinitis are prevalent childhood conditions.
  • Understanding their distinct pathologies is crucial for effective management.
  • Early childhood assessment is vital for long-term respiratory health.

Purpose of the Study:

  • To investigate nasal eosinophilia and airway patency in young children with allergic and nonallergic rhinitis.
  • To differentiate the underlying pathologies of these common childhood rhinitis types.
  • To assess the association between rhinitis diagnosis and nasal inflammation/obstruction.

Main Methods:

  • A cohort of 255 six-year-old children was studied.
  • Nasal eosinophilia and airway patency (acoustic rhinometry) were assessed.
  • Data were analyzed using a multivariate model, accounting for relevant covariates.

Main Results:

  • Allergic rhinitis correlated significantly with irreversible nasal airway obstruction.
  • Both allergic and nonallergic rhinitis showed significant nasal eosinophilia, more pronounced in allergic rhinitis.
  • Nonallergic rhinitis did not show changes in nasal airway patency.

Conclusions:

  • Allergic and nonallergic rhinitis exhibit distinct pathologies.
  • Allergic rhinitis is associated with eosinophilic inflammation and irreversible nasal obstruction, suggesting structural changes.
  • Nonallergic rhinitis involves eosinophilic inflammation but not significant airway obstruction in young children.
Abstract

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