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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Fatal Scedosporium prolificans infection in a paediatric patient with acute lymphoblastic leukaemia

Min J Song, Jang H Lee, Nam Y Lee

    Mycoses
    |August 12, 2009
    PubMed

    Insights

    Scedosporium prolificans infections are fatal in immunocompromised patients due to drug resistance. This case highlights a fatal Scedosporium prolificans infection in a child with leukemia despite treatment.

    Area of Science:

    • Mycology
    • Infectious Diseases
    • Hematology

    Background:

    • Scedosporium prolificans is a fungus causing infections in immunocompromised individuals.
    • Disseminated infections are often fatal due to neutropenia and antifungal drug resistance.

    Observation:

    • A pediatric Korean patient with acute lymphoblastic leukemia underwent induction chemotherapy.
    • The patient developed severe sepsis from Scedosporium prolificans infection.

    Findings:

    • Treatment with itraconazole was ineffective.
    • The patient succumbed to the infection within 6 days of hospital admission.

    Implications:

    • This case underscores the challenges in treating Scedosporium prolificans infections.
    • It highlights the need for novel therapeutic strategies against resistant fungal pathogens in immunocompromised hosts.

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