Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Prismatic Beams: Problem Solving

Prismatic Beams: Problem Solving

In the design of a supported timber beam subjected to a distributed load, both the beam's physical dimensions and the timber's characteristics, such as its grade and species, are critical. These factors determine the allowable stress values, which are crucial for calculating the necessary beam depth to ensure structural integrity and safety.
The design begins with analyzing the beam as a free body to identify moments and force balances, thereby determining support reactions. Next, the designer...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

SERIPH: A Two-Step Extraction Protocol for Selective Enrichment of Semi-Extractable RNAs.

RNA (New York, N.Y.)·2026

Same author

Perihilar Biliary Neuroendocrine Carcinoma Treated With Perioperative Chemotherapy and Radical Liver Surgery: A Thought-Provoking Case.

The American journal of case reports·2026

Same author

Blocky proline/glutamine patterns in the SFPQ intrinsically disordered region dictate paraspeckle formation as a distinct membraneless organelle.

RNA (New York, N.Y.)·2026

Same author

Downregulation of <i>NEAT1</i> due to loss of TDP-43 function exacerbates motor neuron degeneration in amyotrophic lateral sclerosis.

Brain communications·2025

Same author

Architectural RNAs: blueprints for functional membraneless organelle assembly.

Trends in genetics : TIG·2025

Same author

Unraveling architectural RNAs: Structural and functional blueprints of membraneless organelles and strategies for genome-scale identification.

Biochimica et biophysica acta. General subjects·2025

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy (FSM)

Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy (FSM)

Published on: August 5, 2009

How to build a paraspeckle.

Yasnory T F Sasaki¹, Tetsuro Hirose

¹Functional RNomics Team, Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 2-42 Aomi, Koutou, Tokyo 135-0064, Japan. y.t.f.sasaki@aist.go.jp

|August 12, 2009

Summary

This summary is machine-generated.

Noncoding RNAs are key components of paraspeckles, which are nuclear suborganelles. This discovery advances our knowledge of paraspeckle molecular dynamics and their physiological functions.

More Related Videos

Measuring the Behavioral Effects of Intraocular Scatter

Measuring the Behavioral Effects of Intraocular Scatter

Published on: February 18, 2021

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Related Experiment Videos

Last Updated: Jun 21, 2026

Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy (FSM)

Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy (FSM)

Published on: August 5, 2009

Measuring the Behavioral Effects of Intraocular Scatter

Measuring the Behavioral Effects of Intraocular Scatter

Published on: February 18, 2021

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Area of Science:

Cell Biology
Molecular Biology
Genetics

Background:

Paraspeckles are nuclear bodies with poorly understood functions.
The molecular composition of paraspeckles has been a subject of intense research.

Purpose of the Study:

To identify the molecular components of paraspeckles.
To elucidate the role of noncoding RNAs in paraspeckle formation and function.

Main Methods:

High-throughput sequencing to identify RNA species.
Biochemical fractionation to isolate paraspeckle components.
Functional assays to determine the role of identified RNAs.

Main Results:

Noncoding RNAs were identified as essential components of paraspeckles.
Specific noncoding RNAs were found to be crucial for paraspeckle integrity and dynamics.
These noncoding RNAs play a significant role in the physiological functions mediated by paraspeckles.

Conclusions:

Noncoding RNAs are integral to paraspeckle structure and function.
This finding provides new insights into the molecular mechanisms governing paraspeckles.
Further research into noncoding RNA-paraspeckle interactions will illuminate their physiological relevance.