Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hindsight Biases01:12

Hindsight Biases

Hindsight bias leads you to believe that the event you just experienced was predictable, even though it really wasn’t. In other words, you knew all along that things would turn out the way they did. Can you relate this to the phrase "Hindsight is 20/20" now?
Robbers Cave04:49

Robbers Cave

During the 1950s, the landmark Robbers Cave experiment demonstrated that when groups must compete with one another, intergroup conflict, hostility, and even violence may result. At the Oklahoman summer camp, two troops of boys—termed the Rattlers and the Eagles—took part in a week-long tournament. During this time, their negativity culminated in derogatory name-calling, fistfights, and even vandalism and destruction of property. However, this work also revealed that such tension could be...
The Stanford Prison Experiment03:20

The Stanford Prison Experiment

The famous and controversial Stanford Prison Experiment, conducted by social psychologist Philip Zimbardo and his colleagues at Stanford University, demonstrated the power of social roles, social norms, and scripts.
Purposive Learning01:22

Purposive Learning

E. C. Tolman emphasized the purposiveness of behavior — the idea that much of our behavior is goal-directed. For instance, employees who aim for a promotion work diligently to meet their targets. Tolman argued that when classical conditioning and operant conditioning occur, the organism acquires certain expectations. In classical conditioning, a child might fear a dog because they expect it to bite. In operant conditioning, a person might consistently work overtime because they expect a bonus...
Modeling in Therapy01:26

Modeling in Therapy

Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in situations...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes.

The New England journal of medicine·2025
Same author

36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO.

Hypertension research : official journal of the Japanese Society of Hypertension·2024
Same author

Patient-Level Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure 6 Months After Medication Escalation: The RADIANCE Clinical Trial Program.

Circulation·2023
Same author

Comparison of tirzepatide and dulaglutide on major adverse cardiovascular events in participants with type 2 diabetes and atherosclerotic cardiovascular disease: SURPASS-CVOT design and baseline characteristics.

American heart journal·2023
Same author

General versus central adiposity as risk factors for cardiovascular-related outcomes in a high-risk population with type 2 diabetes: a post hoc analysis of the REWIND trial.

Cardiovascular diabetology·2023
Same author

Endovascular Ultrasound Renal Denervation to Treat Hypertension: The RADIANCE II Randomized Clinical Trial.

JAMA·2023

Related Experiment Video

Updated: Jun 21, 2026

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
09:27

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles

Published on: August 25, 2020

Lessons learned from the ONTARGET and TRANSCEND trials.

Jan Basile1

  • 1Ralph H. Johnson VA Medical Center, Medical University of South Carolina, Charleston, SC 29401, USA. Jan.Basile@med.va.gov

Current Atherosclerosis Reports
|August 12, 2009
PubMed
Summary

Blocking the renin-angiotensin-aldosterone system (RAAS) is crucial for managing hypertension and cardiovascular disease (CVD). Key trials like ONTARGET and TRANSCEND demonstrate the efficacy of RAAS inhibitors in high-risk patients.

More Related Videos

Training Laboratory Rabbits to Refine Routine Husbandry Procedures
05:21

Training Laboratory Rabbits to Refine Routine Husbandry Procedures

Published on: February 16, 2024

Related Experiment Videos

Last Updated: Jun 21, 2026

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
09:27

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles

Published on: August 25, 2020

Training Laboratory Rabbits to Refine Routine Husbandry Procedures
05:21

Training Laboratory Rabbits to Refine Routine Husbandry Procedures

Published on: February 16, 2024

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Cardiovascular disease (CVD) is a leading cause of death in the US.
  • The renin-angiotensin-aldosterone system (RAAS) plays a significant role in blood pressure regulation and CVD.
  • Targeting the RAAS is a key strategy for treating hypertension and cardiovascular conditions.

Purpose of the Study:

  • To review the outcomes of the ONTARGET and TRANSCEND trials.
  • To discuss the role of RAAS inhibition in managing high-risk cardiovascular patients.
  • To identify clinical practice issues regarding RAAS-targeting therapies.

Main Methods:

  • Analysis of data from the Ongoing Telmisartan Alone and in Combination with Ramipril Global endpoint Trial (ONTARGET).
  • Review of findings from the Telmisartan Randomized Assessment Study in ACE-Intolerant Subjects with Cardiovascular Disease (TRANSCEND).

Main Results:

  • Both trials demonstrated the effectiveness of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in reducing CVD.
  • Specific outcomes related to telmisartan in combination therapy and in ACE-intolerant patients were highlighted.

Conclusions:

  • RAAS inhibition is a vital therapeutic approach for patients with hypertension and existing CVD.
  • Clinical decisions on selecting RAAS-targeting therapies require careful consideration of trial data and patient profiles.