Related Experiment Video
Updated: Jun 21, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
[Correlation between serum MMP-2 and MMP-9 in patients with acute myocardial infarction before and after PCI]
Feng Dai1, Gui-lin Xiao, Jing Pan
1Department of Emergency, Xiangya Hospital, Central South University, Changsha 410008, China. daifeng1999@126.com
Aim:
To investigate the correlation between serum MMP-2 and MMP-9 in patients with acute myocardial infarction (AMI) before and after PCI.
Methods:
The enzymatic activity and protein expression level of serum MMP-2 and MMP-9 in 56 patients with AMI and 20 control subjects were detected by the SDS-PAGE enzymograph and Western blot before and 1-7 days after PCI. The correlation between MMP-2 and MMP-9 was also analyzed.
Results:
The enzymatic activity and protein expression level of serum MMP-2 and MMP-9 in 56 patients with AMI were both significantly higher than those in the control subjects before and after PCI (P<0.01). The enzymatic activity and protein expression level of serum MMP-2 and MMP-9 in patients with AMI began to increase on the first day and were at peak on the third day (P<0.01). They began to decrease on the fifth day after PCI (P<0.05). The enzymatic activity of serum MMP-2 was correlated positively with that of MMP-9 (P<0.01). The protein expression level of serum MMP-2 was also correlated positively with that of MMP-9 (P<0.01).
Conclusion:
The serum MMP-2 and MMP-9 may be related to inflammatory injuries after myocardial ischemia and reperfusion. MMP-2 can be regarded as an important marker of inflammation as MMP-9 in the pathogenesis of AMI.
Related Concept Videos
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:30Acute Coronary Syndrome I: Introduction
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:28Acute Coronary Syndrome IV: Interprofessional Care