[How to evaluate and treat heart failure with preserved left ventricular ejection fraction]

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Updated: Jun 21, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Alain Cohen Solal1, François Tournoux, Florence Beauvais

  • 1Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Denis Diderot, INSERM U942, Paris, France. alain.cohen-solal@lrb.aphp.fr

Therapie
|August 12, 2009
PubMed

Insights

Heart failure with preserved ejection fraction is now the most common type due to aging populations. Current treatments are ineffective, though research is ongoing for this condition.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Heart failure with preserved ejection fraction (HFpEF) is the predominant form of heart failure.
  • Its prevalence is increasing due to global population aging.
  • HFpEF shares a similar prognosis to heart failure with reduced ejection fraction.

Purpose of the Study:

  • To review the epidemiology, diagnosis, pathophysiology, and therapeutic strategies for HFpEF.
  • To highlight the diagnostic tools and current treatment limitations for HFpEF.

Main Methods:

  • Review of current literature on HFpEF.
  • Analysis of diagnostic methods including B-type natriuretic peptide and Doppler echocardiography.
  • Evaluation of existing and investigational therapeutic approaches.

Main Results:

  • HFpEF is the most frequent heart failure presentation.
  • B-type natriuretic peptide and Doppler echocardiography aid in diagnosis.
  • No current treatment has demonstrated definitive efficacy, with limited clinical trials.

Conclusions:

  • HFpEF management remains challenging due to a lack of effective therapies.
  • Renin-angiotensin system antagonists show potential but lack proven efficacy.
  • Further research and clinical trials are crucial for advancing HFpEF treatment.

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