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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jun 21, 2026

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Other targetable sarcomas.

Veridiana Pires de Camargo1, Matt van de Rijn, Roberta Maestro

  • 1Sarcoma Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Seminars in Oncology
|August 12, 2009
PubMed
Summary
This summary is machine-generated.

This review explores targeted therapies for sarcoma, focusing on chromosomal changes like HDM2 and CDK4 amplification in dedifferentiated liposarcoma and other survival pathways for novel systemic treatments.

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Related Experiment Videos

Last Updated: Jun 21, 2026

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Aneuploid tumors, such as dedifferentiated liposarcoma, exhibit specific genetic alterations.
  • Amplification of HDM2 and CDK4 are key chromosomal changes in these tumors, presenting therapeutic targets.

Purpose of the Study:

  • To review target selection strategies for various sarcoma subtypes.
  • To highlight novel techniques for identifying new systemic therapeutic approaches in sarcoma treatment.

Main Methods:

  • Review of existing literature on sarcoma genetics and targeted therapies.
  • Analysis of chromosomal abnormalities and cancer cell survival pathways.
  • Examination of emerging techniques for therapeutic target identification.

Main Results:

  • Specific chromosomal changes (e.g., HDM2, CDK4 amplification) offer targets for systemic therapy in aneuploid sarcomas.
  • Cancer cell survival pathways (angiogenesis, apoptosis) represent additional therapeutic avenues.
  • New techniques are being developed to identify novel treatment strategies.

Conclusions:

  • Targeted therapies based on genetic alterations and survival pathways hold promise for sarcoma treatment.
  • Continued research into novel techniques will expand therapeutic options for sarcoma patients.