Human beta defensin-3 engineered keratinocyte sheets constructed by a magnetic force-based tissue engineering technique
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Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
Published on: February 26, 2015
Akira Ito1, Tetsuya Takahashi, Yoshinori Kawabe
1Department of Chemical Engineering, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Journal of Bioscience and Bioengineering
|August 12, 2009
Abstract:
A multilayered keratinocyte sheet overexpressing human beta defensin-3 (HBD-3) gene was prepared by the magnetic force-based tissue engineering technique. The cell sheet demonstrated significant antimicrobial activity, indicating that the therapeutic introduction of HBD-3 gene into cell sheets may provide a new gene therapy strategy for infectious diseases.
