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Updated: Jun 21, 2026

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Synthesis, functionalization and photo-Bergman chemistry of enediyne bioconjugates
Paul LaBeaume1, Krista Wager, Danielle Falcone
1Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States.
Abstract:
Methodology is outlined for the chemical synthesis of versatile photo-Bergman enediyne building blocks and their conjugates. Routes to both mono and bis conjugated enediyne templates are detailed together with representative examples of their bioconjugates, nanoconjugates, PEG derivatives and water soluble salts. The immunocompetence of antibody conjugates is retained, and application in the form of reagents for photodynamic therapy (PDT) advanced.
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