Dangers of 'single-point pharmacology' in receptor studies. GABAA receptor: complex picture confused

The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors.

British journal of pharmacology·2011

Impact of subunit positioning on GABAA receptor function.

Biochemical Society transactions·2006

Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit.

Neuropharmacology·2004

The relative amount of cRNA coding for gamma2 subunits affects stimulation by benzodiazepines in GABA(A) receptors expressed in Xenopus oocytes.

Neuropharmacology·2002

Subunit arrangement of gamma-aminobutyric acid type A receptors.

The Journal of biological chemistry·2001

Differential cross talk of ROD compounds with the benzodiazepine binding site.

Molecular pharmacology·2001

Epigenetic programming via lysine-specific demethylase 1 regulates responses to immune checkpoint blockade.

Trends in pharmacological sciences·2026

Heterochiral peptides reshaping class B1 GPCR agonism.

Trends in pharmacological sciences·2026

Targeting CH25H restores p62-mediated α-synuclein clearance.

Trends in pharmacological sciences·2026

B cells enter the synaptic conversation.

Trends in pharmacological sciences·2026

Lipophagy and lipid droplets in neurodegeneration.

Trends in pharmacological sciences·2026

Bias from within: intracellular allosterism and the ICL2 hub.

Trends in pharmacological sciences·2026

Eucalyptusins A-I, formyl phloroglucinol meroterpenoids with cytotoxic activities from the fruit of Eucalyptus globulus Labill.

Fitoterapia·2026

ESCAPE enables receptor-specific chemogenetic dissection of GPCR signaling.

Cell chemical biology·2026

Shared structural alterations, divergent functional responses in salivary and lacrimal glands: A conceptual framework from Cdc42-mediated polarity disruption.

Journal of oral biosciences·2026

Raman a banana: mapping banana peel composition and ripening process by Raman spectroscopy.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026

Endocannabinoid plasma concentrations and their relationship with clinical outcome and cannabis use in antipsychotic-naïve first episode psychosis.

Psychiatry research·2026

Trends in microextraction-based sample pretreatment for food flavonoids.

Food chemistry·2026

Related Experiment Videos

Dangers of 'single-point pharmacology' in receptor studies. GABAA receptor: complex picture confused

Related Concept Videos

The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors.

Impact of subunit positioning on GABAA receptor function.

Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit.

The relative amount of cRNA coding for gamma2 subunits affects stimulation by benzodiazepines in GABA(A) receptors expressed in Xenopus oocytes.

Subunit arrangement of gamma-aminobutyric acid type A receptors.

Differential cross talk of ROD compounds with the benzodiazepine binding site.

Epigenetic programming via lysine-specific demethylase 1 regulates responses to immune checkpoint blockade.

Heterochiral peptides reshaping class B1 GPCR agonism.

Targeting CH25H restores p62-mediated α-synuclein clearance.

B cells enter the synaptic conversation.

Lipophagy and lipid droplets in neurodegeneration.

Bias from within: intracellular allosterism and the ICL2 hub.

Eucalyptusins A-I, formyl phloroglucinol meroterpenoids with cytotoxic activities from the fruit of Eucalyptus globulus Labill.

ESCAPE enables receptor-specific chemogenetic dissection of GPCR signaling.

Shared structural alterations, divergent functional responses in salivary and lacrimal glands: A conceptual framework from Cdc42-mediated polarity disruption.

Raman a banana: mapping banana peel composition and ripening process by Raman spectroscopy.

Endocannabinoid plasma concentrations and their relationship with clinical outcome and cannabis use in antipsychotic-naïve first episode psychosis.

Trends in microextraction-based sample pretreatment for food flavonoids.

Related Experiment Videos

Dangers of 'single-point pharmacology' in receptor studies. GABAA receptor: complex picture confused

Related Concept Videos

Related Articles