Double versus single intrauterine insemination for unexplained infertility: a meta-analysis of randomized trials
Nikolaos P Polyzos1, Spyridon Tzioras1, Davide Mauri1
1Section of Obstetrics and Gynaecology and Public Health, Panhellenic Association for Continual Medical Research, Athens, Greece.
Objective:
To investigate the effect of double versus single intrauterine insemination (IUI) per treatment cycle in women with unexplained infertility.
Design:
Meta-analysis of randomized controlled trials.
Main Outcome Measure(S):
Clinical pregnancy rates per couple.
Intervention(S):
Electronic searches of the Cochrane Central Trials Registry and Medline without year and language restriction through March 2009; hand searching of the abstract books of the European Society of Human Reproduction and Embryology and American Society for Reproductive Medicine annual meetings (2001-2008).
Result(S):
Six randomized trials, involving 829 women, were included in the analysis. Fifty-four (13.6%) clinical pregnancies were recorded for treatment with double IUI and 62 (14.4%) for treatment with single IUI. There was no significant difference between the single and double IUI groups in the probability for clinical pregnancy (odds ratio, 0.92; 95% confidence interval, 0.58-1.45; P=0.715).
Conclusion(S):
Double IUI offers no clear benefit in the overall clinical pregnancy rate in couples with unexplained infertility.
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